Amyloid β - protein (4-42) is a fragment of β - amyloid protein, the reduction of sequence reduces the difficulty of synthesis, and the solubility is relatively better. In terms of storage conditions and half-life, there was no difference between the Amyloid β-Protein (4-42) and other β - amyloid proteins.
A lot of β - folds will lead to test of ninhydrin false-positive phenomenon in the synthesis process of Amyloid β-Protein (4-42), which may lead to low purity of crude products and affect the purification and separation in the later stage; secondly, the extremely strong hydrophobicity will bring difficulties in the dissolution of Amyloid β-Protein (4-42), which needs to grasp the experimental details in the generation process.